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Search Results for " PTK2 protein tyrosine kinase 2 "

ターゲット

阻害剤

天然化合物

292

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T2314	PF-431396		FAK , PYK2
	PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).		FAK , PYK2
T9576	AMP-945		FAK
	AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.		FAK
T6997	SU6656		FAK , Akt , Src
	SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.		FAK , Akt , Src
T9973	FAK-IN-7		FAK
	FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.		FAK
T2001	PF-573228	PF 573228	Apoptosis , FAK
	PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.		Apoptosis , FAK
T5480	BI-4464		FAK , Ligands for Target Protein for PROTAC
	BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC		FAK , Ligands for Target Protein for PROTAC
T2465	PF-562271	PF562271,PF 562271	FAK , PYK2 , CDK
	PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).		FAK , PYK2 , CDK
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T6177	PF-562271 besylate	PF-00562271 Besylate	FAK , PYK2 , CDK
	PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc...		FAK , PYK2 , CDK
T24730	Roslin 2 bromide	Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK , p53
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects.		FAK , p53
T2281	GSK2256098	GSK 2256098,GSK-2256098,GTPL7939	Apoptosis , FAK
	GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.		Apoptosis , FAK
T2655	CEP-37440	CEP37440	FAK , ALK
	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).		FAK , ALK
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T1918	NVP-TAE 226	TAE226	Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.		Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
T1996	Defactinib	PF-04554878,VS-6063	FAK
	Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.		FAK
T21768	PF-562271 hydrochloride	PF-562271 HCl	FAK , PYK2 , CDK
	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...		FAK , PYK2 , CDK
T0263	Chloropyramine hydrochloride	Nilfan,Alergosan,Halopyramine hydrochloride	FAK , VEGFR , Histamine Receptor
	Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.		FAK , VEGFR , Histamine Receptor
T2609	Masitinib	AB1010	Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck
	Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet...
T1950	PND-1186	PND1186,PND 1186,VS-4718,SR-2516	Apoptosis , FAK
	PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).		Apoptosis , FAK
T7119	Y15	1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14	FAK
	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.		FAK

Compounds

Target: FAK, Akt, Src

Target: Apoptosis, FAK

BI-4464

T5480

Synonym:

Target: FAK, Ligands for Target Protein for PROTAC

PF-562271

T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Roslin 2 bromide

T24730

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: FAK, p53

GSK2256098

T2281

Synonym: GSK 2256098,GSK-2256098,GTPL7939

Target: Apoptosis, FAK

Target: FAK, IGF-1R, ALK

NVP-TAE 226

T1918

Synonym: TAE226

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

Defactinib

T1996

Synonym: PF-04554878,VS-6063

Target: FAK

PF-562271 hydrochloride

T21768

Synonym: PF-562271 HCl

Target: FAK, PYK2, CDK

Chloropyramine hydrochloride

T0263

Synonym: Nilfan,Alergosan,Halopyramine hydrochloride

Target: FAK, VEGFR, Histamine Receptor

Masitinib

T2609

Synonym: AB1010

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

PND-1186

T1950

Synonym: PND1186,PND 1186,VS-4718,SR-2516

Target: Apoptosis, FAK

Y15

T7119

Synonym: 1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14

Target: FAK

カタログ番号	製品名	別名	ターゲット
TN1433	Batatasin III		FAK , Others , Akt
	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-...		FAK , Others , Akt
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T3122	Fangchinoline	Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline	Apoptosis , FAK , HIV Protease , Autophagy
	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.		Apoptosis , FAK , HIV Protease , Autophagy

天然物製品

Batatasin III

TN1433

Synonym:

Target: FAK, Others, Akt

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Fangchinoline

T3122

Synonym: Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-00871	LAYN Protein, Human, Recombinant (hFc)	Human	HEK293
	Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet...
TMPY-00849	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-00850	ST2/IL-1 RL1 Protein, Human, Recombinant	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-02358	CD98 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr...
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293
	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149)	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli.
TMPY-04844	BTN3A1 Protein, Human, Recombinant (His)	Human	HEK293
	BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmemb...
TMPY-01935	C-Kit Protein, Human, Recombinant (His)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-02367	Neuropilin-1 Protein, Human, Recombinant (isoform b, His)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-02096	TACI Protein, Human, Recombinant (His)	Human	HEK293
	Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF...
TMPY-01359	ST2/IL-1 RL1 Protein, Human, Recombinant (His)	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc)	Human	HEK293
	CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is ...
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a)	Human	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-05427	CD19 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01199	CD74 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-01985	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 cells.
TMPJ-00335	TGFBR2 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPY-04829	G-CSF Protein, Human, Recombinant	Human	HEK293
	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-04051	C-Kit Protein, Human, Recombinant (hFc)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-02432	VEGF164 Protein, Rat, Recombinant	Rat	Baculovirus-Insect Cells
	Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-00392	PAM Protein, Human, Recombinant (His)	Human	HEK293
	Peptidylglycine alpha-amidating monooxygenase (PAM) is highly expressed in neurons and endocrine cells, where it catalyzes one of the final steps in the biosynthesis of bioactive peptides. PAM is also expressed in unicel...
TMPY-04644	PDGFB Protein, Human, Recombinant (His)	Human	Yeast
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-01871	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)	Human	HEK293
	Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine recept...
TMPY-01717	VEGF164 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-05414	NKG2D/CD314 Protein, Mouse, Recombinant (hFc)	Mouse	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-02231	TrkB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-01442	DMBT1 Protein, Human, Recombinant (His)	Human	HEK293
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d...
TMPY-00747	Nectin-2 Protein, Human, Recombinant (His)	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-02500	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC c...
TMPY-03425	Tau Protein, Human, Recombinant (His)	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are...
TMPY-01315	EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var...
TMPY-03959	CHST11 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family. CHST11 localizes to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondro...
TMPJ-01041	FGF-12 Protein, Human, Recombinant	Human	E. coli
	Fibroblast Growth Factor 12 (FGF-12) is a member of the fibroblast growth factor (FGF) family. FGF-12 is probably involved in nervous system development and function. FGF-12 lacks the N-terminal signal sequence present i...
TMPY-03331	DPEP2 Protein, Human, Recombinant (His)	Human	HEK293
	DPEP2 (MBD-2) belongs to the membrane-bound dipeptidase family. There are three members of this family as membrane-bound dipeptidase-1 (MBD-1),membrane-bound dipeptidase-2 (MBD-2) and membrane-bound dipeptidase-3 (MBD-3)...
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